STK11 - Wikipedia
the STK11 gene and its product, such as the homologous protein sequences in different factor binding sites on their promoters, their phylogenetic relationship. - SERINE/THREONINE PROTEIN KINASE 11; STK11 - LKB1 - STK LKB1. HGNC Approved Gene Symbol: STK Cytogenetic location: 19p 5 days ago Decreases in LKB1 expression by HBx protein-mediated p53 SSfsX13) in the STK11 gene causing PJS in a Chinese female without the statistical relationship between LKB1 expression and prognosis of PCa patients.
LKB1 was not induced in cells transfected with miRa-3p Taken together, our results establish that the HspCdc37 complex controls both the stability and activity of the LKB1 kinase.DNA transcription and translation [HD animation]
A novel de novo mutation was identified in exon 5 of STK11, that resulted in a translational frameshift leading to termination at codon in a child with Peutz-Jeghers syndrome ERalpha repressively modulates the expression of LKB1 at the transcriptional level. The relatively high frequency of LKB1 mutations in mucinous bronchioloalveolar carcinoma patients may therefore suggest its involvement in lung carcinogenesis, at least in mucinous bronchioloalveolar carcinoma.
This reports for the first time the presence of frequent LKB1 inactivating mutations in human lung cancer. The LKB1 gene alteration is rare in Japanese patients with lung adenocarcinoma, and is generally limited to male smokers.
STK11 serine/threonine kinase 11 [ (human)]
Adiponectin treatment increases the expression of tumor suppressor gene, LKB1 in breast cancer cells. A novel missense mutation in the nuclear localization signal coding region of the LKB1 gene was detected in 10 tumor samples from patients with head and neck cancer. Six different single-nucleotide substitutions were also observed in the introns. LKB1 loss of function promotes lung cancer malignancy through remodeling of extracellular matrix microenvironment, and identify LOX as a potential target for disease treatment in lung cancer patients.
LKB1 mutations are associated with lung adenocarcinomas.
Data show that the deletions, ranging from 2. In hyperinsulinemic girls with androgen excess, the STK11 rs single nucleotide polymorphism influences insulin sensitivity and metformin efficacy High LKB1 is associated with Peutz-Jeghers syndrome polyps.
Thus, loss of LKB1 expression in normal cells may contribute to the formation of malignancies. Identified homozygous deletions in the HeLa and SiHa cells. Data show that somatic loss of LKB1 is associated with underphosphorylation of endogenous Crtc1, enhanced Crtc1 nuclear localization.
The results presented here enlarge the spectrum of mutations of the STK11 gene by identifying a de novo mutation in a PJS patient and further support the hypothesis that STK11 mutations are disease-causing mutations for PJS. LKB1 protein might inhibit malignant biological behavior of A cells partly by down-regulating the tyrosine-phosphorylated level of STAT3 protein. LKB1 was found to bind to ERalpha and was found to be recruited to the promoters of estrogen responsive genes, altering their expression.
LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas and cervical cancers.
Results place LKB1 in a coactivator role for ERalpha signaling, broadening the scientific scope of this tumor suppressor kinase and laying the groundwork for the use of LKB1 as a target for the development of new therapies against breast cancer.
Results suggest that in multiple cell types the signaling pathways engaged by several stimuli converge upon PKC-zeta-dependent LKB1 phosphorylation at serinewhich directs the nucleocytoplasmic transport of LKB1 and consequent AMPK activation. LKB1 is thus a major cervical tumor suppressor, demonstrating that acquired genetic alterations drive progression of HPV-induced dysplasias to invasive, lethal cancers Growth of cervical cancer cells was inhibited through activation of CAMKK2 and LBK1.
Overexpression of the LKB1 gene inhibits lung carcinoma cell proliferation partly through degradation of c-myc protein. Observational study of gene-disease association and gene-environment interaction.
LKB1 has now been demonstrated to play a crucial role in pulmonary tumorigenesis, controlling initiation, differentiation, and metastasis.
Identification of STK11 mutations in patients and their relatives can help to improve the clinical management. Two novel LKB1 mutations in Colombian Peutz-Jeghers syndrome patients Part of a cascade that functions as a critical determinant of hepatocyte proliferation during liver regeneration after partial hepatectomy. A polymorphism in the STK11 gene is associated with low ovulatory response to treatment with metformin alone in a prospective, randomized trial. They tended to occur more commonly in adenocarcinomas than in squamous cell carcinomas.
LKB1 may have a role in lung cancer [review] Results enlarge the spectrum of mutations of the STK11 gene by identifying a novel de novo mutation in a PJS patient and further support the hypothesis that STK11 mutations are disease-causing mutations for PJS with or without a positive family history rosiglitazone is able to acutely stimulate NO synthesis in cultured endothelial cells by an AMP-activated protein kinase-dependent mechanism, likely to be mediated by LKB1 PKCzeta mediates LKB1-dependent Akt inhibition in response to peroxynitrite, resulting in endothelial apoptosis.
Marked reduction of LKB1 expression in high-grade neuroendocrine tumors of the lung suggests a possible role of LKB1 inactivation in its tumorigenesis. Observational study of gene-disease association and gene-gene interaction. HuGE Navigator Meta-analysis and HuGE review of genotype prevalence, gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing.
HuGE Navigator Observational study of genotype prevalence. HuGE Navigator Observational study of gene-disease association.
LKB1 gene is located in the short arm of chromosome 19, which is frequently deleted in many tumors of sporadic origin. Recombinant LKB1 produces significant growth inhibition and cell-cycle arrest.
STK11 serine/threonine kinase 11 [ (human)]
LKB1 gene mutations were relatively rare in Japanese patients with lung cancer compared with Caucasian patients. N33, STK11 19p13 and TP53 might play a role in the development of metastasis in larynx and pharynx squamous cell carcinomas.
A role has been identified for the polarity regulator LKB1 in the development of c-Myc- resistant cell organization. Ectopic expression of cyclooxygenase-2 and endogenous biosynthesis of eicosanoids also inhibited LKB1 activity in MCF-7 cells.
Serine/threonine-protein kinase STK11
Martin and St Johnston demonstrated that Drosophila Lkb1 is required for the early anterior-posterior polarity of the oocyte, and for the repolarization of the oocyte cytoskeleton that defines the embryonic anterior-posterior axis. Lkb1 is phosphorylated by Par1 in vitro, and overexpression of Lkb1 partially rescues the Par1 phenotype. These 2 kinases, therefore, function in a conserved pathway for axis formation in flies and worms. Lkb1 mutant clones also disrupt apical-basal epithelial polarity, suggesting a general role in cell polarization.
STK11 (serine/threonine kinase 11)
Martin and St Johnston showed that Drosophila Lkb1 is phosphorylated by protein kinase A PKA; see at a conserved site that is important for its activity. Thus, Martin and St Johnston suggested that Drosophila and human LKB1 may be functional homologs, and that it may be the loss of cell polarity that contributes to tumor formation in individuals with PJS.
Upon LKB1 activation, single cells rapidly remodeled their actin cytoskeletons to form apical brush borders. The second box outlined by the dashed lines illustrates the location of the nuclear localization signal NLS and the purple box indicates the prenylation motif. This protein is believed to contain a putative cytoplasmic retention signal not shown. Description amino acids, Expression Ubiquitous, especially high expression in the testis and fetal liver. Localisation Found in both the nucleus and the cytoplasm.
STK11 was shown to associate and activate the pseudokinase, STRAD, resulting in the reorganization of non-polarized cells so they form asymmetrical apical and basal structures.
AMPK is a protein kinase cascade that plays an important role in regulating energy homeostasis.